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Chinese President Xi Jinping will not attend President-elect Donald Trump’s inauguration, but he is sending Vice President Han Zheng as his special representative.

The decision, announced Friday in China by the foreign ministry, came more than a month after Trump extended the unusual invitation to Xi, a break from tradition since no heads of state have previously made an official visit to the US for the inauguration.

“We stand ready to work with the new US government to enhance dialogue and communication, properly manage differences, expand mutually beneficial cooperation, jointly pursue a stable, healthy and sustainable China-US relations and find the right way for the two countries to get along with each other,” the ministry’s spokesperson said when announcing the decision.

Other foreign leaders have spoken about being invited to Trump’s inauguration, including Argentinian President Javier Milei and Italian Premier Giorgia Meloni. The offices of Ecuadorean President Daniel Noboa and Paraguayan President Santiago Peña have also said they were invited and were planning to attend.

Sun Yun, director of the China program at the Washington-based think tank Stimson Center, said the move by Xi means “China is willing to forego protocol and cater to what Trump wants.”

“It indicates that China is willing to talk, negotiate and make efforts to reach deals,” Sun wrote.

Danny Russel, vice president for international security and diplomacy at the Asia Society Policy Institute, said Beijing is hedging by sending Han instead of Xi.

“Zero chance that Xi Jinping would allow himself to be potted plant at Donald Trump’s triumphal coronation. At the same time, ensuring that China extends enough courtesy to avoid bruising Trump’s ego,” Russel wrote. Han’s mission, the former American diplomat said, is “symbolic, not substantive.”

The dispatch of Han comes as the US-China rivalry is set to intensify. Several of Trump’s nominees for key Cabinet positions are known China hawks, including Sen. Marco Rubio of Florida, who’s nominated as secretary of state. Rubio called China “the most potent, dangerous and near-peer adversary this nation has ever confronted” during his confirmation hearing on Wednesday, when members of the Senate Foreign Relations Committee urged Rubio to make countering China a top priority.

Beijing prefers leader-level talks, which it believes could help guide the bilateral relations, while Trump likes to deal with world leaders directly.

As president, Xi has traveled abroad for state visits and summits. But he did not attend the coronation of King Charles III, nor did he go to the funeral of Queen Elizabeth II or the memorial service for Nelson Mandela. Instead, he sent vice presidents. Han was his special representative for King Charles III’s coronation. When Trump invited Xi to the inauguration in December, it was widely believed that Xi was unlikely to come.

This post appeared first on cnn.com

Securing the nation’s border will feature large in South Dakota Gov. Kristi Noem’s opening remarks to Senate lawmakers on Friday as she works to lock down her confirmation as the country’s next secretary of homeland security, Fox News Digital exclusively learned. 

‘Securing our homeland is a serious, sacred trust that must be relentlessly pursued and can never be taken for granted. Being safe within our borders is an American right, yet Americans feel less safe than they have in decades. For the first time in 30 years, more than 40% of Americans are afraid to walk alone at night within a mile of their home,’ Noem is expected to tell the Senate Homeland Security and Governmental Affairs Committee on Friday morning in her opening remarks. 

‘President-Elect Trump is going to change that.’

Fox News Digital exclusively obtained a copy of the South Dakota Republican’s opening statement, which is set to not only showcase Noem’s vision for a secure and safe nation, but also underscore her rural roots and life in the Mount Rushmore State. 

‘I’m a wife, mother, a grandmother, a farmer, a rancher, a businesswoman, and a governor,’ a copy of the remarks states. ‘I have spent my life in rural America. I understand what it means to work hard every day to build a better future for our kids and our communities. I come before you today with a deep sense of responsibility and humility as the nominee to lead the Department of Homeland Security. And also a commitment to the more than 330 million Americans, whom we will serve to work to keep them safe and secure in their homes, their communities and their country.’

President-elect Donald Trump announced NOem as his pick to lead DHS shortly after his decisive win over Harris in November, pointing to her efforts to secure the southern border amid the immigration crisis under the Biden administration. 

The DHS oversees U.S. Customs and Border Protection, Immigration and Customs Enforcement, the U.S. Secret Service and the Federal Emergency Management Agency. 

Noem’s opening remarks heavily focus on securing the border, including highlighting that she was the first governor to deploy National Guard troops to border states in 2022. She has since repeatedly deployed South Dakota National Guard troops to the southern border in Texas to help stem illegal border crossings as part of Gov. Greg Abbott’s Operation Lone Star. 

‘As a nation, we have the right and responsibility to secure our borders against those who would do us harm. And we must create a fair and lawful immigration system that is efficient and effective and that reflects our values. President Trump was elected with a clear mandate to achieve this mission. Two thirds of Americans support his immigration and border policies, including the majority of Hispanic Americans.’

‘I was the first Governor to send National Guard troops to Texas when they were being overwhelmed by an unprecedented border crisis. If confirmed as Secretary, I will ensure that our exceptional, extraordinary f agents have ALL the tools, resources, and support they need to carry out their mission effectively. The same is true of my commitment to the outstanding men and women of U.S. Immigration and Customs Enforcement. They are responsible for apprehending, detaining, and deporting illegal immigrants. Getting criminal aliens off the streets and out of the country will help make American communities safe again. The bravery and dedication of the Border Patrol and ICE are unmatched, and I will restore dignity to their work,’ the copy of her remarks states. 

Noem is also set to tout her leadership skills in the remarks, including leading the Mount Rushmore State for the last six years, including overseeing thousands of state employees.

‘I have led South Dakota for the last 6 years with a focus every day on making our state safer, stronger, and freer. I have focused every day on making the best decisions not just for right now, but for generations to come. I have overseen a state budget of over $7 billion and a state employee workforce of more than 13,000, including more than 7,000 reporting to the Governor. I have addressed important issues like cybersecurity, human trafficking, drug interdiction, and natural disasters – the same challenges facing so many of you here and the people you represent back at home.’

Noem will join the Senate committee with a bevy of high-profile endorsements under her belt, including at least eight police groups and unions throwing their support behind the South Dakota governor for DHS. 

Crises have also broken out in the waning days of the Biden administration, including a terrorist attack that shook New Orleans early New Year’s Day and raging fires in the Los Angeles area. Following the attack, Noem picked up an endorsement from Republican Louisiana Gov. Jeff Landry, who warned now is ‘no time to play around’ while calling on Senate lawmakers to swiftly confirm Noem. While the massive and historically Democrat firefighter union, the International Association of Firefighters, also endorsed Noem while the California wildfires first raged earlier this month. 

Noem is expected to note that, if confirmed, she will emphasize resiliency in the face of disaster. 

‘I recognize that homeland security is not only about prevention but also about resilience. When disasters strike, as we know they will, the Department of Homeland Security must be ready to respond swiftly, efficiently, and effectively to protect the lives and property of Americans. As governor, I have worked with FEMA in response to a dozen natural disasters in South Dakota. These have included historic floods, tornados, blizzards, wildfires, a derecho, and even a global pandemic. As Secretary, I will enhance our emergency preparedness and strengthen FEMA’s capabilities. We will ensure that no community is left behind and that life-saving services like electricity and water are quickly restored,’ she said. 

She is set to also turn her attention to cybersecurity in the nation, vowing to prioritize protecting the nation’s energy grids and financial systems from ‘foreign adversaries and criminal actors.’

‘In the coming days, we have to think and plan bigger, faster, and smarter. I fully acknowledge that we in Washington do not have all the answers. Therefore, I will leverage public-private partnerships and advance cutting-edge, state-of-the-art technologies to protect our nation’s digital landscape. I have a proven track record doing this in South Dakota. I have helped make Dakota State University a global leader in cybersecurity education because we recognize the need to address this emerging threat. I will take this proactive approach if given the opportunity to serve as Secretary,’ the copy of the remarks states.

Noem has served as South Dakota’s governor since 2019, gaining national attention and praise from conservatives during the pandemic when her state eschewed lockdown orders and mask mandates common in liberal states such as California and New York. 

‘I am committed to working with this committee, with Congress, and with the dedicated men and women of the Department of Homeland Security to fulfill our mission. Together, we can ensure that the United States remains a beacon of freedom, safety, and security for generations to come. Thank you for the opportunity and honor to appear before you today. I look forward to your questions. I hope to earn your trust and, hopefully, your vote as we embark on this critical work together,’ she is expected to say on Friday morning. 

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President-elect Donald Trump’s return to power on January 20 is one of the most anticipated of any modern presidency and is likely to be one of the most consequential. America’s friends and adversaries are watching closely and thinking hard about their relationships with the United States.  

Trump’s election-winning ‘America first’ vision foresees a strong America in the world that is respected and seeking peace through strength. America’s allies need to hear the message the American people have sent and calibrate their partnerships in order to work with and alongside the U.S. to stand up for the joint interests that unite us.  

The astute among America’s allies will be observing the comprehensive nature of Trump’s November election win. On the numbers alone – across the popular vote and spanning different demographic groups – this victory demonstrated a campaign that responded to the central concerns and interests of a vast swath of the American people.  

Trump’s great skill as a political campaigner is to tap into sections of an electorate that feel unheard. Having been at the core of three winning UK election campaigns, I know well that this ability to build such a coalition across the country is the holy grail and key to political success.    

His victory can be seen to represent the many Americans who work hard, yet for whom life is a struggle; communities that fear prices at the checkout, witness illegal migration accelerating and see opportunities for their children diminishing. Working people who feel their concerns have been either ignored or, worse, stigmatized by traditional politics.  

Five decades as a politician and latterly as a businessman have taught me always to hear your electorate and listen to your customer. Alliances between foreign nations need to do the same. Foreign relationships must hear these messages and evolve rapidly to deliver for their citizens. The Atlantic alliance cannot simply enjoy its glorious past – it must adapt to new threats and technological challenges. 

I am listening hard to the message that millions of Americans delivered in November. Tuning into a similar set of concerns among large chunks of the British public, such as addressing the rising cost of living and making our streets safe again, won my party a comprehensive victory in July last year.  

As I prepare to start my role as custodian of a decades-old ‘special relationship,’ I reflect on my work with multiple U.S. administrations – Republican and Democrat – across the intensive U.S.-U.K. relationship. I see three areas of major potential for expanded partnership between Britain and today’s America: economic growth, national security and foreign policy realism.  

Trump Wants Greenland, or the Panama Canal

It is taken for granted that the U.K. and U.S. are the closest defense and intelligence partners in the world. This work is invaluable and keeps millions of Americans and Brits secure each day. But our national security partnerships must be clearer in how they keep our people safe.  

Sensible European governments will be thinking hard about their defense partnership with the U.S. While Europe has made an enormous contribution to defending against an aggressive and reckless Russia on its doorstep – spending over $150 billion in Ukraine – Americans are right to ask if NATO partners can do more to reduce the U.S.’s out-sized burden. 

The U.K. has been at the forefront of driving NATO allies to increase their national defense spending and will continue to advocate for partners to pay their way.  

Growing the economy and increasing living standards is at the top of the U.K. government agenda. The U.S. and U.K. are each other’s largest single investors with over $960 billion in mutual investment. Our businesses create over a million jobs in each other’s country, and we have a strong and balanced trading relationship, worth over $375 billion with the U.S. figures showing a trade surplus with the U.K.  

Having co-founded a global business in the U.S. and employed Americans in London, I have witnessed firsthand the synergies created by these ties. We are innovators and deal-making nations. And as only two western countries on the planet with trillion-dollar tech sectors, we must do more together to invent, develop and industrialize the technologies of tomorrow.  

We are hungry to trade more and innovate more with America – but we must do so in a way that generates good, well-paid jobs for all our citizens and keeps us ahead in the global race.  

Finally, we must operate in the world we find not the world we would ideally like. Since I was last in government, many of our adversaries have become emboldened. Iran has been seriously set back in recent months but is still a thoroughly malign force in the region. We must not ever allow it to become nuclear armed.  

It is taken for granted that the U.K. and U.S. are the closest defense and intelligence partners in the world. This work is invaluable and keeps millions of Americans and Brits secure each day. But our national security partnerships must be clearer in how they keep our people safe.  

The Chinese government I have observed intensively over the past 20 years is more aggressive abroad and controlling at home and in many sectors, now directly challenges Western governments and our values.  

Trump’s straight talking has earned him a resounding victory in his own country. His straight-talking and deal-making instincts overseas should be viewed by allies as a significant opportunity to bring entrepreneurial thinking and urgency to resolving foreign policy that needs real-world solutions.  

The Trump administration will rightly put the needs of Americans first. But in its closest allies, it will find old partners open to new ways of dealing with the current world – to protect, enrich and build opportunities for Americans and our own citizens alike.    

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– Republican National Committee (RNC) chair Mike Whatley says his job going forward in the 2025 elections and 2026 midterms is straight forward.

‘It’s really critical for us to make sure that the Trump voters become Republican voters,’ Whatley said in an exclusive national digital interview with Fox News on the sidelines of the RNCs’ winter meeting, which is being held in the nation’s capital.

Republicans enjoyed major victories November’s elections, with President-elect Trump defeating Vice President Kamala Harris to win back the White House, the GOP flipping control of the Senate from the Democrats, and holding on to their razor-thin majority in the House.

Whatley, who was interviewed on Thursday on the eve of the formal vote by the RNC for the chair to continue in his position steering the national party committee, said the GOP needs ‘to cement those gains’ made in the 2024 elections.

‘We’re going to go right back to the building blocks that we had during this election cycle, which is to get out the vote and protect the ballot,’ Whatley emphasized. 

The RNC chair pointed to ‘the lessons that we learned’ in the 2024 cycle ‘about going after low propensity voters, about making sure that we’re reaching out to every voter and bringing in new communities,’ which he said helped Republicans make ‘historic gains among African American voters, among Asian American voters, among Hispanic voters, young voters and women voters.’

Speaking a couple of days before the president-elect’s inauguration, Whatley emphasized that once Trump’s in the White House, ‘we’re going to go right back to the RNC. We’re going to roll up our sleeves and get to work. We’ve got a couple of governor’s races…that we’re going to be working on in ‘25.’

But Whatley said ‘everything is focused on ‘26,’ when the party will be defending its majorities in the House and Senate, ‘because that is going to determine, from an agenda perspective, whether we have two years to work with or four. And America needs us to have a four-year agenda.’

‘What we’re going to be doing is making sure that we are registering voters,’ Whatley said. ‘We’re going to be…communicating with the folks that we need to turn out.’

Pointing to the 2024 presidential election, he said ‘it’s the same fundamentals.’

But he noted that ‘it’s not just seven battleground states’ and that the 2026 contests are ‘definitely going to be a very intense midterm election cycle.’

While Democrats would disagree, Whatley described today’s GOP as ‘a common sense party…this is a party that’s going to fight for every American family and for every American community.’

Referring to former Democrats Robert F. Kennedy Jr. and former Rep. Tulsi Gabbard, whom Trump has nominated to serve in his second administration’s cabinet, Whatley touted ‘the fact that we have two former Democratic presidential candidates who are going to be serving in the president’s cabinet. That shows you that this is a commonsense agenda, a commonsense team, that we’re going to be moving forward with.’

Last March, as Trump clinched the 2024 GOP presidential nomination, he named Whatley to succeed Ronna McDaniel as RNC chair. Whatley, a longtime Trump ally and a major supporter of Trump’s election integrity efforts, had served as RNC general counsel and chair of the North Carolina Republican Party. 

In December, Trump asked Whatley to continue during the 2026 cycle as RNC chair.

‘I think we will be able to talk when we need to talk,’ Whatley said when asked if his lines of communication with Trump will be limited now that the president-elect is returning to the White House. ‘We’re going to support the president and his agenda. That does not change. What changes is his ability from the White House to actually implement the agenda that he’s been campaigning on.’

Trump is term-limited and won’t be able to seek election again in 2028. Vice President-elect Sen. JD Vance will likely be considered the front-runner for the 2028 GOP nomination.

Whatley reiterated what he told Fox News Digital in December, that the RNC will stay neutral in the next race for the GOP nomination and that the party’s ‘got an amazing bench.’

‘You think about the talent on the Republican side of the aisle right now, our governors, our senators, our members of Congress, people that are going to be serving in this administration. I love the fact that the Republican Party is going to be set up to have a fantastic candidate going into ’28,’ he highlighted.

Unlike the DNC, which in the 2024 cycle upended the traditional presidential nominating calendar, the RNC made no major changes to their primary lineup, and kept the Iowa caucuses and the New Hampshire primary as their first two contests.

Asked about the 2028 calendar, Whatley reiterated to Fox News that ‘I have not had any conversations with anybody who wants to change the calendar, so we will wait and see what that looks like as we’re going forward. We’re at the RNC meetings this week and having a number of conversations with folks, but that is not a huge push.’

‘I don’t think that changing the calendar really helped the Democrats at all,’ Whatley argued. ‘And I think that us, making sure that we are working our system the way that we always have, is going to be critical.’

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A Pakistani court on Friday sentenced the country’s already-imprisoned former Prime Minister Imran Khan and his wife to 14 and seven years in jail after finding them guilty of corruption, officials and his lawyer said.

The couple are accused of accepting a gift of land from a real estate tycoon in exchange for laundered money when Khan was in power.

Prosecutors say the businessman, Malik Riaz, was then allowed by Khan to pay fines that were imposed on him in another case from the same laundered money of 190 million British pounds ($240 million) that was returned to Pakistan by British authorities in 2022 to deposit to the national exchequer.

Khan has denied wrongdoing and insisted since his arrest in 2023 that all the charges against him are a plot by rivals to keep him from returning to office.

Khan, who was ousted in a no-confidence vote in parliament in April 2022, had previously been convicted on charges of corruption, revealing official secrets and violating marriage laws in three separate verdicts and sentenced to 10, 14 and seven years respectively. Under Pakistani law, he is to serve the terms concurrently — meaning, the length of the longest of the sentences.

This is a developing story.

This post appeared first on cnn.com

Discoveries made by companies in the genetics sector help support every other life science industry in a variety of ways.

One of the genetic sector’s major contributions is the discovery of new genetic drivers of diseases. Genetic testing has grown substantially over the last few years thanks to advances in technology; growth has also been spurred by an increase in chronic diseases and the continuing development of test kits for therapeutic areas with unmet medical needs.

Gene therapy is also a huge driver of growth in the overarching genetics market. It’s estimated that in 2024 this market was worth US$8.98 billion, and is expected to reach an impressive US$57.13 billion by 2034, growing at a compound annual growth rate of 18.52 percent over that time period.

This important segment of the life science market is focused on how genes can help treat or prevent serious conditions in patients. This includes the potential for healthcare professionals to implement gene therapy at the cellular level instead of using medication or surgery, replacing “faulty” genes with new ones to potentially cure diseases.

Pharma and biotech companies often dabble in genetics along with their core disciplines, meaning that some firms may also have operations in other areas. The top NASDAQ genetics stocks listed below have products related to gene therapy, genetic testing, genetically defined cancers and rare genetic diseases.

Data for this list of genetics stocks on the NASDAQ was collected on January 15, 2024, using TradingView’s stock screener, and stocks with market caps above US$50 million were considered.

1. Avidity Biosciences (NASDAQ:RNA)

Year-over-year gain: 149.51 percent
Market cap: US$3.33 billion
Share price: US$27.87

Avidity Biosciences is a biopharma firm developing a new form of RNA therapy called antibody oligonucleotide conjugates (AOC) that targeted the genes causing rare muscle diseases. Through its proprietary AOC platform, Avidity is conducting clinical development programs for three rare muscle diseases: AOC 1001 for myotonic dystrophy type 1, AOC 1044 for Duchenne muscular dystrophy and AOC 1020 for facioscapulohumeral muscular dystrophy. The company is also working to expand its pipeline into cardiology and immunology.

Avidity announced on February 20, 2024, that the US Food and Drug Administration (FDA) granted rare pediatric disease designation to its investigational therapy AOC 1044 for the treatment of Duchenne muscular dystrophy in people with certain mutations. Shares in the company rose more than 43 percent following the news to US$20.11 by March 1.

The FDA awarded breakthrough therapy designation to Avidity’s lead clinical development program, AOC 1001 for the treatment of myotonic dystrophy type 1, in early May.

Avidity’s stock price jumped by nearly US$10 to US$38.36 per share on June 12, the day Avidity shared positive initial data from the Phase 1/2 trial of AOC 1020, which “demonstrat(ed) unprecedented and consistent reductions of greater than 50% in DUX4 regulated genes, trends of functional improvement, and favorable safety and tolerability in people living with facioscapulohumeral muscular dystrophy.”

By August 9, shares in the company had risen by a further 22 percent to US$46.95 per share after it announced positive data from its Phase 1/2 trial for AOC 1044 in people living with Duchenne muscular dystrophy, including results showing a significant increase of 25 percent of normal in dystrophin production and a reduction of creatine kinase levels to near normal.

Shares in Avidity reached a yearly peak of US$52.50 on November 13, a day after the company introduced its first two precision cardiology development candidates targeting the root cause of genetic diseases of the heart.

2. Wave Life Sciences (NASDAQ:WVE)

Company Profile

Year-over-year gain: 134.08 percent
Market cap: US$1.75 billion
Share price: US$11.47

Wave Life Sciences is another clinical-stage firm focused on unlocking insights from human genetics to deliver RNA-based medicines. The company’s PRISM platform is targeting both rare and prevalent disorders. Its pipeline includes clinical programs for Duchenne muscular dystrophy, alpha-1 antitrypsin deficiency and Huntington’s disease, as well as a preclinical program in obesity.

Wave’s stock value made its biggest gains mostly in the fourth quarter of 2024. On September 24, Wave announced positive interim data from its ongoing Phase 2 FORWARD-53 study of WVE-N531 being investigated in boys with Duchenne muscular dystrophy. The news led shares in the company to grow in price by more than 68 percent to close at US$9.01 on September 25.

Wave’s share price received its biggest boost on October 16, rising more than 70 percent to US$14.90, when the company shared positive proof-of-mechanism data demonstrating the “first-ever therapeutic RNA editing in humans” achieved in its RestorAATion-2 trial of WVE-006 in alpha-1 antitrypsin deficiency.

Shares in Wave reached their highest yearly peak at US$16.44 on November 8.

3. UniQure (NASDAQ:QURE)

Year-over-year gain: 127.85 percent
Market cap: US$747.59 million
Share price: US$13.99

UniQure is a gene therapy company focused on patients with severe medical needs. In November 2022, the FDA approved the company’s gene therapy Hemgenix (etranacogene dezaparvovec), which is the world’s first gene therapy for hemophilia B. Today, uniQure’s proprietary gene therapy pipeline includes treatments for patients with Huntington’s disease, refractory temporal lobe epilepsy, ALS and Fabry disease.

UniQure had its first big leap in its share value after the company announced a positive interim data update showing slowing of disease progression in its Phase 1/2 trials of AMT-130 for Huntington’s disease on July 9, 2024. The stock shot up more than 167 percent to US$10.12 per share.

Its next significant move to the upside came on December 10 when shares reached US$15.30 after uniQure notified shareholders it had reached an agreement with the FDA on an accelerated approval pathway for AMT-130.

“This is an important milestone for the Huntington’s disease community as it puts us on the most rapid and efficient pathway to deliver a potentially life-changing therapy to people living with this devastating neurodegenerative disorder,’ said Walid Abi-Saab, chief medical officer of uniQure. “We have initiated BLA readiness activities and look forward to further engaging with the FDA in the first half of 2025 to discuss our statistical analysis plan and the technical CMC requirements.”

Shares in uniQure hit a yearly high of US$18.05 on January 2, 2025.

4. Sangamo Therapeutics (NASDAQ:SGMO)

Year-over-year gain: 114.05 percent
Market cap: US$229.51 million
Share price: US$1.10

Sangamo Therapeutics is a genomic medicine company developing multiple platforms for developing gene therapies, such as gene editing and cell therapy, to address the unmet needs of patients afflicted with serious neurological diseases.

On July 24, 2024, the company reported on positive topline results from the Phase 3 AFFINE trial evaluating giroctocogene fitelparvovec, an investigational gene therapy for the treatment of adults with moderately severe to severe hemophilia A. The company was co-developing the therapy with and licensing it to Pfizer (NYSE:PFE). Sangamo’s share value more than doubled from July 23 to reach US$0.92 per share on July 29.

On October 22, Sangamo announced that the FDA has given the company a clear regulatory pathway to accelerated approval for its wholly owned gene therapy product candidate isaralgagene civaparvovec (ST-920), for the treatment of Fabry disease. Sangamo said it expects a potential biologics license application submission in the second half of 2025. Shares in the genetic stock rose more than 69 percent in one day to US$1.54, and continued climbing over the following weeks to its highest yearly peak of US$2.87 on November 9.

However, the company was hit by a surprise at the end of 2024, and announced on December 30 that Pfizer decided to terminate its global collaboration and license agreement with Sangamo for the hemophilia A treatment. The termination is effective April 21, 2025, at which time Pfizer will return full rights to the therapy to Sangamo.

‘We are committed to exploring the optimal path forward for this important treatment, including seeking the right partner with the focus and understanding of the genomic medicine commercial environment to bring this medicine to patients,’ Sangamo CEO Sandy Macrae stated in the release. The news gave the stock a more than 56 percent hair cut to US$1.01 per share.

5. Stoke Therapeutics (NASDAQ:STOK)

Year-over-year gain: 88.67 percent
Market cap: US$502.66 million
Share price: US$9.49

Stoke Therapeutics is another biotech company with a focus on developing RNA medicine. With its proprietary research platform TANGO, which stands for targeted augmentation of nuclear gene output, the company is developing antisense oligonucleotides to selectively restore protein levels.

Stoke’s first product candidate, zorevunersen (STK-001), is in clinical testing for the treatment of Dravet syndrome, a severe genetic epilepsy. The company is also developing STK-002 for the treatment of autosomal dominant optic atrophy, an inherited optic nerve disorder.

On March 25, 2024, Stoke announced “landmark new data” supporting the potential for its STK-001 product candidate to become the first disease-modifying medicine for the treatment of patients with Dravet syndrome. A few days later, the company’s share price had risen by 118 percent to reach US$14.17 per share.

Shares of Stoke Therapeutics hit a yearly peak of US$17.52 on June 13.

Other good news coming out of Stoke during 2024 included new positive data out of its Phase 1/2a and open-label extension studies for STK-001 on September 10, as well as the FDA granting STK-001 breakthrough therapy designation on December 4 for the treatment of Dravet syndrome ‘with a confirmed mutation, not associated with gain-of-function, in the SCN1A gene.’

Securities Disclosure: I, Melissa Pistilli, hold no direct investment interest in any company mentioned in this article.

This post appeared first on investingnews.com

The vanadium market is poised for shifts this year driven by a projected rise in demand from energy storage and steel sectors.

Energy storage systems that utilize vanadium redox flow batteries (VRFBs) are gaining traction as renewable energy deployment accelerates, boosting demand for high-purity vanadium.

However, global supply remains constrained due to limited mining projects and geopolitical uncertainties, particularly in China and Russia, key producers.

Additionally, environmental regulations and advancements in recycling technology may influence supply dynamics. Market observers will also watch potential price volatility tied to steel demand, the largest consumer of vanadium globally.

In September 2024 China introduced new standards for rebar which are anticipated to increase high quality vanadium demand in the segment.

“Production of rebar with the new standards will increase per annum vanadium nitrogen consumption by roughly 15 percent,” A July Fastmarkets report noted. “That calculation is based on China’s 2023 rebar production volume.”

“Vanadium demand in steel alloys will rise in 2025 due to change in Chinese rebar standards. However, expected demand rise in steel will not be as high as estimated from battery manufacturing in the medium term due to slow down in the Chinese construction industry,” said Piyush Goel, commodities consultant at CRU Group via email.

He added: “Vanadium demand in batteries is estimated to rise rapidly, this rise in demand will primarily come from China due to targeted government policies due towards vanadium redox flow batteries (VRFBs).”

China, which is the leading producer of vanadium, is also expected to drive global demand in the year ahead.

“Rise in vanadium demand in the medium term (till 2029) is estimated to be heavily concentrated in China because we estimate VRFB demand to pick-up faster in China compared to other regions,” he said. “Similarly, Chinese rebar standards also changed – requiring higher vanadium intensity steel. Due to the rapid rise in domestic vanadium demand, China is likely to become a net importer of vanadium as the Chinese market goes into deficit from surplus.”

Vanadium demand faces rebar challenges, with limited boost from batteries

Even though Fastmarkets is calling for a 15 percent uptick in vanadium demand for rebar, this will only bring demand back up to previous levels.

As Erik Sardain, principal analyst for Project Blue explained, China’s weak construction market has caused a 15 percent year-on-year decline in domestic rebar construction.

Despite positivity in the VRFB space, Sardain doesn’t expect this to offset the lower rebar demand.

The principal analyst went on to point out that quantifying the amount of vanadium used in batteries and energy storage is challenging to tally. He also questioned the forecasted demand trends from the battery segment.

“I think the market got it wrong for one main reason, because the market is assuming that the vanadium redox battery for the storage system is going to be something worldwide,” he said. “And at Project Blue, we don’t think it’s going to be global. We think it’s going to be primarily China.”

He attributes this to the types of installations that are being deployed utilizing VRFB energy storage systems, explaining that China is using it to power grids while other countries are using the technology for small scale applications.

Taking a more optimistic and long-term view, CRU’s Goel sees more viability in the battery and energy storage segments.

“VRFBs will have a considerable impact on the vanadium industry through the next two decades but will play a minor role in the energy storage space – accounting for only 3.5 percent of total battery energy storage installations by 2035,” said Goel.

“Although VRFBs will make up a small portion of total energy storage, they are significant consumers of vanadium and will consume the majority of global vanadium in 2035, compared to ~6 percent in 2024,” he added.

Supply picture blurred by geopolitics

As the ongoing Ukraine war and tensions between the US and China and the US and its allies grows, many metals and minerals have faced volatility. These tensions have disrupted critical metals markets, spurring policymakers to fast-track new supply chains.

China’s restrictions on gallium and germanium exports in August 2023 escalated to a complete ban on shipments to the US in December 2024, intensifying global supply concerns.

Potential export caps, and tariffs threaten to disrupt already fragile supply chains, however Goel doesn’t foresee these issues impacting the vanadium market.

“Similar trade restrictions are unlikely in vanadium, as most of the recent rise in vanadium demand is coming from China, which means China is likely to become a net importer if no new capacity is opened,” he said. “This also means that should China become import reliant for a meaningful share of vanadium, which is to be used in 2 significant national industries (steel and energy storage), vanadium will move up in criticality matrices for China – moving nearer to materials like iron ore, potash, and high purity quartz.”

As demand in China picks up, Sardain anticipates the Asian nation will ramp up production.

“With the current geopolitical environment, there is absolutely no way that China is going to rely on imports of vanadium,” he said.

According to Goel, China isn’t the only country that is looking to be less reliant on imports.

“Governments worldwide have recognized vanadium as a critical mineral, leading to increased support for emerging vanadium projects,” said Goel.

He referenced Australian company Vecco Group which received an AU$3.8 million grant to advance the feasibility and design of a high-purity vanadium project in Brisbane.

“However, such grants are not enough to bring a project from conception to production. The current low vanadium pricing environment is a barrier to increasing ex-China capacity,” he added.

Australia to dominate growing supply capacity

While China will dominate the vanadium market narrative in 2025, Australia is positioning itself to become a production hub.

In addition to Vecco’s government support the company’s project was granted “coordinated project” status by the Queensland government. The status designation streamlines approvals for major developments with significant impacts, centralizing assessments and enabling public consultation.

In late December, Explorer and developer QEM (ASX:QEM) also received coordinated project status from Queensland’s Office of the Coordinator-General for its Julia Creek vanadium and energy project.

According to a July release, a scoping study completed on the Julia Creek deposit affirms the company’s aims to produce approximately 10,571 tonnes of 99.95 percent pure V2O5 and 313 million litres of transport fuel annually over a 30 year mine life.

In mid-January Australian Vanadium (ASX:AVL,OTC Pink:ATVVF) was granted environmental approval for its Gabanintha vanadium project in Western Australia.

The approval covers a mine, concentrator, processing plant, and supporting infrastructure, including a bore field and camp. The company is updating its Optimised Feasibility Study to integrate Gabanintha into its Australian Vanadium Project, one of the largest and highest-grade vanadium deposits.

Trends to watch

Underscoring the magnitude of weakness in the 2024 vanadium market Sardain recounted the factors that impeded price growth.

He explained that despite several factors that should have boosted vanadium demand, the market remained surprisingly weak. Chinese monetary stimulus measures and stricter rebar standard enforcement failed to drive prices higher.

Russian vanadium pentoxide exports to China have dried up, and supply uncertainties persist in South Africa. These conditions, which typically would have supported price increases, have had little impact, highlighting the subdued demand, especially in China.

“To be really honest, I was expecting the market to pick up in the second half of 2024,” he said.

Sardain continued: “I was expecting this to happen because I was looking at the interest rate in Europe, the ECB cutting interest rate. I was expecting some kind of recovery for the European economy. I was expecting the Chinese government to be more proactive. I was expecting the property market in China to stabilize. So, I was expecting some kind of rebound in the second half, which didn’t take place.”

Although the 2024 market didn’t perform to expectation, Sardain sees promise in the months ahead.

“I think that the market is currently bottoming out. I believe that we are very close to the stabilization of the property market in China. Whether it’s going to happen in Q1 or Q2 I don’t know, but definitely and maybe some kind of very, very, very mild recovery in the second half [of the year],” he said.

Highlighting the market’s positive fundamentals CRU’s Goel also sees a price rebound in 2025.

“We are estimating a global supply deficit in 2025 due to change in rebar standards and rise in vanadium battery demand, causing vanadium prices to rise,” said Goel. “ As more supply comes online in 2026 and 2027, by 2027 vanadium prices will come down when compared to 2025 prices, but crucially remain higher than the pricing in the last 12 months.”

Securities Disclosure: I, Georgia Williams, hold no direct investment interest in any company mentioned in this article.

This post appeared first on investingnews.com

For Erfle, interest from generalist investors is the key missing ingredient, but it may finally return this year.

‘That’s what we need — we need to get that generalist investor interest back into this sector. They left in 2012, 2013 and they haven’t returned,’ he explained during the conversation.

‘That’s created this incredible opportunity in gold stocks, and especially in juniors. We’ve got a lot of them that are bifurcating higher and doing well, but most are still underowned and definitely being ignored by the generalist investor.’

Even so, Erfle suggested that market participants be cautious in 2025.

‘Be very careful this year in this market. Build up some cash, have some physical gold, have some junk silver just in case,’ he said. ‘Personally, as far as my investments are concerned … I’ve never had a cash position this large before, because I’m really concerned about the volatility and the chaos that I think 2025 is going to bring.’

Watch the interview for more of his thoughts on gold and silver.

Securities Disclosure: I, Charlotte McLeod, hold no direct investment interest in any company mentioned in this article.

This post appeared first on investingnews.com

With its manicured garden and spacious interior, the three-story villa was once described as “paradise” by the mother who raised her five children there. And much was done to preserve the household’s tranquility, given its immediate neighbor: the largest and most notorious Nazi concentration camp, Auschwitz.

Inside the family home, Rudolf Höss – the longest serving SS commandant of Auschwitz – dreamt up the most efficient way to kill the millions of Jews, Roma, homosexuals and political prisoners that the Third Reich had decided to eliminate.

Tall trees and a high concrete wall obscured the view and the screams of the camp so that Rudolf’s wife Hedwig and their five children – Klaus, Heidetraud, Brigitte, Hans-Jürgen and Annegret – could live shielded from the atrocities committed just feet from their door.

Theirs was a joyful life. The children played with turtles, cats, rode horses and swam in the nearby river. Meanwhile, the concentration camp’s chimneys spewed smoke as other families were pushed into the gas chambers.

Since Auschwitz was liberated in January 1945, the house at 88 Legionow Street had been in the private hands of a Polish family. But last year it was acquired by the Counter Extremism Project, a New York-based NGO that has sought to combat extremism since 2014.

Within days, this building – a potent symbol of how the Holocaust was orchestrated and a major character in the Oscar-winning movie “The Zone of Interest” – will open its door to visitors in a brand-new form.

The NGO’s plans for the house are twofold: to give a new center to their organization and to open this long closed-off house to the public in time for the 80th anniversary of the liberation of the camp on January 27.

“When you look at this property, the gardens, the fountains, the normal, ordinary life, we’ve been taught since the time of the Holocaust to never forget,” said Mark Wallace, CEO of the Counter Extremism Project. “Eighty years later it’s clear that while essential, “never forgetting” is not enough to prevent the hate and antisemitism that right now grips our society.”

Now, it isn’t just pictures of the Höss’s blissful domesticity that remain, but also diaries, one written by the family’s housekeeper and the other by Rudolf Höss himself. This was not out of choice: After his capture and before his execution, Höss was ordered to write his memoir, giving an insight into the workings of a mind that was both ordinary and chillingly evil.

In it, Höss described himself as man committed to discipline and dedicated to order. He wrote that it was “to protect the mental health” of his guards that he decided to utilize Zyklon B, an insecticide he used to murder as many Jews as effectively as possible.

During Höss’s three and a half years at the camp, four additional gas chambers were built intended for industrialized annihilation. More than 1.1 million people were murdered there, making Auschwitz-Birkenau the deadliest of all the Nazi camps.

The belongings of those deported to the camp on the train tracks leading to Auschwitz, circa 1945.
Survivors of the Auschwitz-Birkenau concentration camp after it was liberated in 1945.

The diary also gave much of the material for 2023’s “The Zone of Interest,” which is almost completely set in the house and its immediate surroundings. The movie highlights the ‘banality of evil,’ a phrase coined by Hannah Arendt, and puts forward the idea that the commandant was just a person, not a monster.

“Human beings did this to other human beings and it’s very convenient for us to try and distance ourselves from them because we think we can never behave this way, but I think we should be less certain than that,” said the movie’s director Jonathan Glazer.

Höss’s diary also helps readers understand more about the family’s life at 88 Legionow Street and the lengths they went to to protect their children. The frosted windows, the high walls, a revved-up motorcycle outside gas chamber number 1 to drown out the cries of the people inside.

In the memoir, Höss also recounts how he watched women and children being taken to the gas chambers.

“A woman approached me and pointed at her four children, who were helping the smallest ones over the rough ground, and whispered, ‘How can you bring yourself to kill such beautiful darling children? Have you no heart at all?’”

After witnessing such scenes, Höss wrote, he would ride his horse to clear his mind.

But at no point did he appear to understand the horror of his actions. He called the extermination of the Jews a “mistake” rather than a crime and something that was the result of obeying too blindly orders from above, given, he says, on the basis of a mistaken ideology.

“Let the general public continue to regard me as a bloodthirsty beast, a cruel sadist, as the mass murderer of millions of human beings: for the masses could never imagine the commandant of Auschwitz in any other light,” Höss wrote. “They will never understand that I, too, had a heart.”

Höss went on the run after the liberation of Auschwitz, but was then captured, becoming the first person at such a senior level to admit the extent of the slaughter at the camp. He was made to testify at the International Military Tribunal at Nuremberg and was later condemned to death by a Polish tribunal.

Höss was hanged from the gallows between the camp and his house in 1947.

The surviving Höss family continued to put a distance between themselves and what Rudolf Höss had done. His wife Hedwig and daughter Brigitte moved to the United States following his execution. In an interview in 2013 with the Washington Post, Brigitte said: “It was a long time ago. I didn’t do what was done. I never talk about it – it is something within me. It stays with me.”

“There must have been two sides to him. The one that I knew and then another.”

As to the house, the plan is for it to open to the public in time for the 80th anniversary commemorations. Work to turn part of the property into a museum and the rest into a workspace will take many months, the Counter Extremism Project says.

“Everyone has or can relate to the “house next door.” But today hatred lurks with ubiquity in houses as close to us as next door. House 88 will take up the fight against destructive hatred, and against extremism and antisemitism,” Wallace said.

The first thing members of the Counter Extremism project did was to attach a mezuzah to the front door, as a way of both reclaiming the house and opening it to all.

This post appeared first on cnn.com

While many stocks may be a risky gamble, dividend stocks can offer less volatility, higher returns and stable passive income.

In this article

    What are dividend stocks?

    Dividend stocks reward their shareholders with regular payments out of company earnings. These payouts may come quarterly, semi-annually or annually. The board of directors is responsible for setting the company’s dividend policy and for determining the size of the dividend payout based on the firm’s long-term revenue outlook.

    The more shares an investor holds in a particular dividend stock, the higher the payment you receive will be. For example, if you own 100 shares of a stock paying an annual cash dividend of $3, you would receive $300 in annual dividends from that company. If that company paid a quarterly dividend, you would receive $75 in dividends every three months for a total of $300 over the course of the year.

    Cash dividend payments are typically sent to shareholders through the investor’s brokerage account. However, companies may also pay out dividends by issuing stock (referred to as a stock dividend), or by offering discounts on stock purchases through dividend reinvestment programs (DRIPs).

    Other dividend types include special dividends, which are one-time payments to holders of common stock that are paid out from a company’s accumulated profits; there are also preferred dividends, which are paid to holders of preferred stock on a quarterly basis at a fixed rate.

    When declaring a dividend, an ex-dividend date is set based on stock exchange rules. This date determines whether or not shareholders in the company are eligible for the dividend payout.

    Those shareholders that purchased stock before the ex-dividend date are entitled to the dividend. Conversely, if you purchased stock on or after the ex-dividend date, the seller will receive the payout and you will have to wait until the next declared dividend to reap the rewards of holding a dividend stock.

    To determine an ex-dividend date, check a company’s dividend announcement, where it should note that the dividend will be paid to stockholders of record up to a certain date.

    Pros and cons of investing in dividend stocks

    There are several advantages to dividend stocks, especially for those who prefer a long-term approach to investing, including acting as a source of income and providing stability.

    Companies that pay stock dividends and DRIPs offer investors the opportunity to grow their holdings. Cash dividend stocks, on the other hand, provide an additional source of income that can be used for things such as your mortgage, vacations, healthcare or a child’s university tuition.

    Another attractive feature of dividend stocks is the security they offer. Companies that are able to pay dividends are often well-managed firms with the ability to generate consistent revenues, even in the face of a volatile market.

    As for taxation on dividend stocks, for investors in the US and Canada, the tax rate on qualified or eligible dividends will typically be lower than other forms of investment income. The dividend tax rate will depend on many factors such as your income, where you live, where the company is based and what kind of account you hold the stock in.

    Both the US and Canada have lowered taxes for dividends on American and Canadian companies, respectively, compared to foreign companies. The amount of tax credit towards dividend income also vary depending on the state or province in which you live.

    In the US, you will be taxed less if your dividends are held in an IRA or a 401(k) plan, but if you receive your dividend payments through a brokerage account, that tax rate will be higher. In Canada, you will not need to pay taxes if your dividend shares are held in a TFSA, and you will only pay taxes on dividends in an RRSP when the funds are withdrawn from the account.

    There are downsides to dividend stocks as well. Firstly, when companies are doling out a portion of the profits to shareholders, less capital is being put back into growing the business. This means that dividend stocks have less potential to gain in value. For investors big on growth stocks, these might not be an ideal portfolio addition. There is also the risk that during a downturn in the markets, a company may be forced to pare down its dividend payments or suspend them entirely.

    There are a number of important metrics typically available through online financial and brokerage websites that investors can use to evaluate whether or not a particular dividend stock is right for their portfolio. The three most useful metrics are the debt-to-equity ratio, the dividend yield and the dividend payout ratio.

    What is debt-to-equity ratio?

    The debt-to-equity ratio calculates the amount of total debt (including financial liabilities) that a company holds compared to total shareholder equity. Basically, it’s a measure of the extent to which a company can cover its debt and is used to evaluate a company’s financial health.

    In the context of dividend stocks, a high debt-to-equity ratio can threaten a company’s ability to maintain its dividend. Avoiding companies with a debt-to-equity ratio higher than two is a good rule of thumb, and ratios below one are typically considered good.

    However, it is important to keep in mind that normal ranges for debt-to-equity ratios do depend on the sector. For example, according to January 2025 data from FullRatio, US companies in most of the mining and metals industries had some of the lowest average debt-to-equity ratios of all industries at around 0.2 or below. However, copper, uranium and oil and gas companies had higher debt-to-equity ratios, with averages falling in a range of 0.46 to 0.98 depending on the industry.

    What is dividend yield?

    While the debt-to-equity ratio can be used to evaluate any stock, the dividend yield is a metric specific to evaluating dividend stocks. The dividend yield is a ratio in percentage form that represents the income paid out to shareholders compared to a company’s share price. This ratio is calculated by dividing the annual dividend payment per share by the current share price, meaning it changes with share price fluctuations.

    Investors can use dividend yields to compare the investment value of a dividend stock with its peers in a given sector. “Dividend yield can help investors evaluate the potential profit for every dollar they invest, and judge the risks of investing in a particular company,” Business Insider states.

    For example, let’s say you are choosing between three dividend stocks in a sector with an average dividend yield of 5 percent. Company A pays an annual dividend of $3 per share and is currently trading at $50, meaning it has a dividend yield of 6 percent. Company B also pays an annual dividend of $3 per share, but its current share price is $100, which is a 3 percent dividend yield. Company C pays a dividend of $4 per share and is trading at $40, giving it a dividend yield of 10 percent.

    Taking into account the average dividend yield for the sector, Company A is the best choice of the three. While Company C has a much higher yield, it’s out of line with the sector average, which might be a signal that the company poses a greater investment risk.

    “While a high dividend yield may be appealing, it doesn’t necessarily mean a stock is a smart investment,” Investopedia states. “Overly high dividend yields may indicate that a company is struggling.”

    Conversely, a dividend yield of below 2 percent may be an indication that the company is more focused on growth and investing back into the business rather than sharing profits with stockholders.

    Most financial advisors say investors should look for companies with dividend yields of between 2 and 6 percent.

    Dividend yields move in the opposite direction of stock prices. In the example above, Company C was previously trading at $80 per share before a massive recall of its product was forecast to cost it millions of dollars in lost revenue, causing a massive selloff. Therefore, its ultra-high dividend yield is a negative signal to investors.

    The example of Company C is another reason why investors would be wise not to pick stocks based on one metric alone.

    What is dividend payout ratio?

    Let’s look at another important tool for evaluating dividend stocks: the dividend payout ratio. The dividend payout ratio helps investors measure the risk associated with a particular company’s dividend payment. The ratio is calculated by dividing total dividends by net income. It tells you how much of the company’s net income goes toward paying dividends.

    If a company’s dividend payout ratio shows it is using all of its income to pay dividends, then its dividend program is likely not sustainable. The closer the ratio is to 100 percent, the more likely a company’s dividend program will be cut once the market cycles into a downturn. Nerd Wallet advises investors to rule out companies with dividend payout ratios of 80 percent or above, while Investopedia reports that companies with dividend payout ratios of less than 50 percent are “considered stable” and have “the potential for sustainable long-term earnings growth.”

    What are dividend aristocrats?

    Investors looking for the most stable, reliable dividend stocks turn to dividend aristocrats, which are are S&P 500 (INDEXSP:.INX) companies known for consistently increasing their dividends for at least 25 years. Dividend aristocrats come out of a broad range of industries, such as energy, pharmaceuticals, consumer goods, technology, precious metals mining, financial services and automotive. Well-known companies that are dividend aristocrats include:

        Are dividend aristocrat stocks good investments?

        It should be noted that even dividend aristocrats are not entirely immune from the havoc a recession can wreak on a company’s financial health.

        “Of the 60 dividend aristocrats that existed in 2007, 16 of them cut or suspended their dividends during the financial crisis,” notes Simply Safe Dividends, which offers the Dividend Safety Score system alongside a suite of portfolio-tracking tools. “While bank stocks accounted for the majority of those cuts, it’s never easy to predict which sector will experience the next shock.”

        During the economic shock induced by the COVID-19 pandemic in 2020, 25 percent of the companies covered by Simply Safe Dividend’s Dividend Safety Score cut their dividends.

        Choosing to invest in a dividend stock generally comes down to your risk tolerance. The best way to mitigate your risk of losing money by investing in a dividend stock is to perform adequate due diligence.

        Securities Disclosure: I, Lauren Kelly, hold no direct investment interest in any company mentioned in this article.

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